Talk:Phenethylamine

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Phenethylamine.

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The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Is this a contradiction?

In the article's lede it states "in orally ingested phenethylamine, a significant amount is metabolized in the small intestine by monoamine oxidase B (MAO-B)". However, further down in the "Detection in bodily fluids" section, it states "β-PEA would not be deaminated in the gut as it is a selective substrate for MAO-B, which is not found in the gut". These two statements are seemingly contradictory as the first one says it's metabolized in the small intestine (which is part of "the gut," is it not?) and the second one says it's not. Wondering if someone with more pharmacokinetics knowledge can clear this up. Lumberjane Lilly (talk) 14:07, 16 September 2021 (UTC)[reply]

Selectivity is not absolute, so MAO-A can do some deamination. Also both MAO-A and MAO-B are found in most tissues. So I am pretty sure that some deamination would occur in the gut, but probably not to completion. Microbiome activity may also play a role as some bacteria may be able to deaminate. See PMID: 18652859. Jaredroach (talk) 12:53, 16 October 2024 (UTC)[reply]

Legal status in US

Phenethylamine is not scheduled but in United States v. McKinney (1996), the Court of Appeals for the Eighth Circuit ruled it to be an analogue of methamphetamine under the Federal Analogue Act. Shall we mention that in the article?

Source (page 40 of the PDF)

Amberkitten (talk) 22:59, 20 June 2024 (UTC)[reply]

we need a side effects section

PEA has many side effects that i can't list because there's no section for it 72.24.174.247 (talk) 22:42, 14 September 2024 (UTC)[reply]

You're welcome to create a section (or subsection). Style-guide frowns on having an empty section...someone's gotta be the first to get the content started. DMacks (talk) 23:00, 14 September 2024 (UTC)[reply]

i don't know how to add it in, but if a side effect section was added in, i know most of the side effects phenethylamine has.

diarrhea, euphoria, nausea and vomiting, disassociation, visual change, hallucinations, psychosis, sedation, stimulation, drunk-like movement, loss of balance, talkativeness, racing heart, mood swings, analgesia, and more. Doxylamine (talk) 09:59, 4 November 2024 (UTC)[reply]

"Β-aminoethylamine" listed at Redirects for discussion

The redirect Β-aminoethylamine has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at Wikipedia:Redirects for discussion/Log/2024 October 16 § Β-aminoethylamine until a consensus is reached. Mdewman6 (talk) 01:38, 16 October 2024 (UTC)[reply]

can someone help add in the part about PEA's affect on depression

there's a study about it.

also, i have a theory with a lot of evidence to back it up, specifically that PEA deficiency in adhd causes depression, and there's also a study where most amphetamines & phenethylamines raised PEA concentrations above 50%. there's also a study where people with adhd are more likely to abuse stimulants.

how i think this all links together is specifically that people with adhd will have increased sensitivity to phenethylamine and have more likely odds of getting recreational effects, but as a result of PEA deficiency they get depression much more easily than the average person. further more, this pea deficiency in those with adhd would make a lot of sense on why people with adhd are more likely to abuse stimulants (mostly amphetamines).

PEA would be great in the treatement of adhd and depression but is often overlooked, we need more research and info on this. i know there's plenty of studies that i read several times over, but i don't see the studies mentioned on this page at all. Doxylamine (talk) 00:32, 27 December 2024 (UTC)[reply]

also, PEA can be active without a MAOI if you take enough. that information not being mentioned is giving a lot of misinfo that PEA is only active with a MAOI to anyone who'd read this page. Doxylamine (talk) 00:33, 27 December 2024 (UTC)[reply]

1 gram minimum, 2-3g being a high dose, 4-5g being a really high dosage. anywhere above 5g is pretty much an overdose. Doxylamine (talk) 00:37, 27 December 2024 (UTC)[reply]

Any WP:MEDRS regarding this theory? IntentionallyDense ^(Contribs) 01:37, 27 December 2024 (UTC)[reply]

check the studies on phenethylamine 72.24.174.247 (talk) 05:01, 30 December 2024 (UTC)[reply]